与α1受体阻断剂无相互作用的药物是()A第三代头孢菌素B西咪替丁C卡马西平D地尔硫䓬E他达拉非
与α1受体阻断剂无相互作用的药物是()
A第三代头孢菌素
B西咪替丁
C卡马西平
D地尔硫䓬
E他达拉非
参考解析
本题考查α1受体阻断剂的药物相互作用。α1受体阻断剂与西咪替丁、地尔硫等CYP3A4抑制剂合用时代谢减少;与卡马西平、苯妥英钠等CYP3A4诱导剂合用,会增加肝脏的代谢;大剂量的α1受体阻断剂与5型磷酸二酯酶抑制剂(西地那非、伐地那非、他达拉非)合用时,患者会发生体位性低血压。故答案选A。
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